ARSENIC INDUCED POLYNEUROPATHY
\ˈɑːsnɪk ɪndjˈuːst pˌɒlɪnjuːɹˈɒpəθɪ], \ˈɑːsnɪk ɪndjˈuːst pˌɒlɪnjuːɹˈɒpəθɪ], \ˈɑː_s_n_ɪ_k ɪ_n_d_j_ˈuː_s_t p_ˌɒ_l_ɪ_n_j_uː_ɹ_ˈɒ_p_ə_θ_ɪ]\
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Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.