\ɐɹˈa͡ʊnd ðə bˈɛnd], \ɐɹˈa‍ʊnd ðə bˈɛnd], \ɐ_ɹ_ˈaʊ_n_d ð_ə b_ˈɛ_n_d]\
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2006 - WordNet 3.0
By Princeton University
2011 - English Dictionary Database
By DataStellar Co., Ltd

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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