APC GENES
\ˌe͡ɪpˌiːsˈiː d͡ʒˈiːnz], \ˌeɪpˌiːsˈiː dʒˈiːnz], \ˌeɪ_p_ˌiː_s_ˈiː dʒ_ˈiː_n_z]\
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Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
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Word of the day
exudative diathesis
- A predisposition to interstitial subcutaneous serous or fibrinous infiltrations; subjects suffer from swollen lymph nodes, thickening of tongue, pruritus, seborrhea, gastric and cardiac crises; the condition is aggravated by pilocarpine, but favorably affected atropine adrenalin.