ANTINEOPLASTIC ALKYLATING AGENTS
\ˌantɪnˌiːə͡ʊplˈastɪk ˈalkɪlˌe͡ɪtɪŋ ˈe͡ɪd͡ʒənts], \ˌantɪnˌiːəʊplˈastɪk ˈalkɪlˌeɪtɪŋ ˈeɪdʒənts], \ˌa_n_t_ɪ_n_ˌiː__əʊ_p_l_ˈa_s_t_ɪ_k ˈa_l_k_ɪ_l_ˌeɪ_t_ɪ_ŋ ˈeɪ_dʒ_ə_n_t_s]\
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A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.