ANOXIC BRAIN DAMAGE
\anˈɒksɪk bɹˈe͡ɪn dˈamɪd͡ʒ], \anˈɒksɪk bɹˈeɪn dˈamɪdʒ], \a_n_ˈɒ_k_s_ɪ_k b_ɹ_ˈeɪ_n d_ˈa_m_ɪ_dʒ]\
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A reduction in brain oxygen supply. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives. (From Adams et al., Principles of Neurology, 6th ed, pp1109-11)
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.