ALZHEIMER TYPE DEMENTIA
\ˈaltsa͡ɪmə tˈa͡ɪp dɪmˈɛnʃə], \ˈaltsaɪmə tˈaɪp dɪmˈɛnʃə], \ˈa_l_t_s_aɪ_m_ə t_ˈaɪ_p d_ɪ_m_ˈɛ_n_ʃ_ə]\
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A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgement, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.