ALTERNATIVE RNA SPLICING
\ɔːltˈɜːnətˌɪv ˌɑːɹˌɛnˈe͡ɪ splˈa͡ɪsɪŋ], \ɔːltˈɜːnətˌɪv ˌɑːɹˌɛnˈeɪ splˈaɪsɪŋ], \ɔː_l_t_ˈɜː_n_ə_t_ˌɪ_v ˌɑː_ɹ_ˌɛ_n_ˈeɪ s_p_l_ˈaɪ_s_ɪ_ŋ]\
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A process whereby multiple protein isoforms are generated from a single gene. Alternative splicing involves the splicing together of nonconsecutive exons during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form messenger RNA. The alternative forms produce proteins in which one part is common while the other part is different.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.