ALPHA 2 CHIMAERIN
\ˈalfə tˈuː t͡ʃˈɪme͡əɹˌɪn], \ˈalfə tˈuː tʃˈɪmeəɹˌɪn], \ˈa_l_f_ə t_ˈuː tʃ_ˈɪ_m_eə_ɹ_ˌɪ_n]\
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A GTPase activating protein that is specific for RAC GTP-BINDING PROTEINS. It is expressed primarily in the brain and may be involved in signal transduction. The alternatively spliced form of CHIMERIN 1 (alpha-2 Chimerin) contains an additional src homology domain and is expressed in both the brain and testes.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.