ALPHA 1 ANTITRYPSIN DEFICIENCY
\ˈalfə wˈɒn ˌantɪtɹˈɪpsɪn dɪfˈɪʃənsi], \ˈalfə wˈɒn ˌantɪtɹˈɪpsɪn dɪfˈɪʃənsi], \ˈa_l_f_ə w_ˈɒ_n ˌa_n_t_ɪ_t_ɹ_ˈɪ_p_s_ɪ_n d_ɪ_f_ˈɪ_ʃ_ə_n_s_i]\
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Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN, leading primarily to degradation of elastin of the alveolar walls, as well as other structural proteins of a variety of tissues. (From Scriver, Beaudet, Sly, & Valle, The Metabolic and Molecular Bases of Inherited Disease, 7th ed, p4125)
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