ALKYLATING ANTINEOPLASTICS
\ˈalkɪlˌe͡ɪtɪŋ ˌantɪnˌiːə͡ʊplˈastɪks], \ˈalkɪlˌeɪtɪŋ ˌantɪnˌiːəʊplˈastɪks], \ˈa_l_k_ɪ_l_ˌeɪ_t_ɪ_ŋ ˌa_n_t_ɪ_n_ˌiː__əʊ_p_l_ˈa_s_t_ɪ_k_s]\
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A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
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Word of the day
hydromorphic
- [Greek] Structurally adapted to an aquatic environment, as organs of water plants.