17,20 LYASE
\sˈɛvəntˌiːn twˈɛnti lˈa͡ɪe͡ɪs], \sˈɛvəntˌiːn twˈɛnti lˈaɪeɪs], \s_ˈɛ_v_ə_n_t_ˌiː_n t_w_ˈɛ_n_t_i l_ˈaɪ_eɪ_s]\
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A steroid hydroxylase system found in the microsomal membrane of the steroid-hormone producing tissues. It catalyzes the 17-hydroxylation of steroids, such as progesterone or pregnenolone in the presence of NADPH and molecular oxygen. This is an important step in the biosynthesis of steroid hormones. EC 1.14.99.9.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.