12 S HETE
\twˈɛlv ˈɛs hˈiːt], \twˈɛlv ˈɛs hˈiːt], \t_w_ˈɛ_l_v ˈɛ_s h_ˈiː_t]\
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A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274 (3):1545-51; J Natl Cancer Inst 1994; 86 (15):1145-51)
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Word of the day
hydromorphic
- [Greek] Structurally adapted to an aquatic environment, as organs of water plants.